Now it's personal: targeting genes boosts cancer survival


Now it's personal: targeting genes boosts cancer survival

Aligning drugs with a patient's genetic profile can add years of life, a new study has found

Henry Bodkin

Treating “incurable” cancer by targeting genes rather than where it is located in the body can “transform” survival chances and give years of extra life, a major new study has found.
The first long-term analysis of patients with difficult-to-treat tumours who underwent gene testing has shown the personalised technique boosted chances of surviving 10 years by a factor of six compared with standard practice.
Oncology experts have called for all cancer patients to be given “next-generation sequencing” to identify the drug that works best for them.
Doctors at the University of Texas analysed the progress of 1,307 patients with a range of cancers including breast, gynaecologic and gastrointestinal.
Of these, 711 were tested to determine the precise molecular abnormalities of their tumour and assigned to the most appropriate clinical drug trial.
Presented at the American Society for Clinical Oncology (Asco) meeting in Chicago, the study showed that 15% of those who underwent matched therapy survived for three years compared with 7% of patients who had unmatched therapy, while 6% of the matched group survived 10 years compared with 1% unmatched.
While overall survival was small in the study because the patients were so ill to start with, the scientists behind it said the relative benefit of matched therapy applies to all cancer patients.
“All patients should have access to next-generation sequencing and I believe in the next few years we are going to see this approach dramatically improving outcomes,” said Professor Apostolia Maria Tsimberidou, who led the research.
“We need to know what is really causing these diseases so we can treat them properly.”
Many of the UK’s National Health Service cancer patients are currently given some form of genetic test; however the use of far more detailed next-generation sequencing is at a relatively early stage.
Tsimberidou said personalised cancer medicines had kept one patient in her clinic alive since 2011 despite suffering from glioblastoma, the aggressive brain cancer that killed former UK cabinet minister Tessa Jowell last month.
Dr Catherin Diefenbach, an Asco expert, said scientists had barely “scratched the surface” of the potential of precision medicine.
“Now with faster and more robust genetic tests, we can help even more patients by treating the cancer based on its genetic make-up rather than solely on its location in the body,” she said.
The new study is the first to directly compare the impact of precision medicine against traditional approaches across many different cancer types for a long period.
Nell Barrie, of Cancer Research UK, said: “Drugs that target changes in a patient’s cancer cells have transformed the way cancer is treated, as this study illustrates.
“Cancer Research UK scientists are currently advancing this tailored approach via several studies aimed at personalising treatments, such as our National Lung Matrix Trial which is matching lung cancer patients to targeted drugs that will work for them – with the ultimate goal of saving more lives by finding the right treatment for each person.”
– © The Daily Telegraph

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