Can SA’s decades-old vaccine regime work against Covid-19?

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Can SA’s decades-old vaccine regime work against Covid-19?

Countries with a long-standing BCG programme are faring far better against the virus, a study has found

Senior science reporter
SA has had universal rollout of the BCG vaccination since 1973.
A step ahead? SA has had universal rollout of the BCG vaccination since 1973.
Image: iSTOCK

It’s too soon to say for sure, but a new study by scientists at the New York Institute of Technology (NYIT) could indicate a major score for SA in the fight against Covid-19.

The study, which is completed but not yet published, suggests that countries with a long-standing and successful BCG (Bacillus Calmette-Guérin) vaccination programme — which SA has had since 1973 — are faring far better against the virus than those that don’t.

Lead researcher Gonzalo Otazu and the team said that “Covid-19 has spread to most countries in the world” and “puzzlingly, the impact of the disease is different in different countries”. 

While these differences are attributed to “differences in cultural norms, mitigation efforts and health infrastructure”, they could also “partially be explained by the different national policies regarding BCG childhood vaccination”.

The vaccination has been reported to offer broad protection against respiratory infections.

The vaccination has been reported to offer broad protection against respiratory infections, and the scientists say they compared a large number of countries’ BCG vaccination policies with the morbidity (rate of infections) and mortality (death rate) for Covid-19.

They found that countries without universal policies of BCG vaccination (like Italy, the Netherlands and the US) have been more severely affected compared with countries with universal and long-standing BCG policies.

The World Health Organisation (WHO) says more clinical trials are needed because it is important to know whether it is indeed the case that the BCG vaccine can reduce disease in those infected with the coronavirus.

Bloomberg reports that the World Health Organisation is “encouraging international groups to collaborate with a study led by Nigel Curtis, head of infectious diseases research at the Murdoch Children’s Research Institute in Melbourne, Australia”.

In that country, the vaccine (which is now about 100 years old) is being given to 4,000 healthcare workers to see if it will protect them.

Similar research is going on in the Netherlands, and may also be rolled out in Boston and other Australian cities, according to Bloomberg.

“We wouldn’t be doing this if we didn’t think that this might work,” Curtis said. “We cannot guarantee that this will work. And of course, the only way to find out is with our trial.”

Meanwhile, the NYIT researchers say that countries that had a late start of universal BCG policy (like Iran, which only introduced the vaccine universally in 1984) had high mortality, consistent with the idea that BCG protects the vaccinated elderly population.

Otazu and the team say that because the vaccine has reduced the number of reported cases in various countries, “BCG vaccination is a potential new tool in the fight against Covid-19”. 

According to the WHO, BCG coverage in SA has remained between 80% and 90%, except in 2017 and 2018 when stock-outs hit the country and the rate dropped to 75% and 70% respectively.