Virgil Abloh, the American-born son of Ghanaian immigrants who became fashion’s highest-profile black designer and the creative mind behind Louis Vuitton’s men’s wear collections, died on Sunday at the age of 41 after a two-year battle with a rare form of cancer.

Abloh, who also worked as a DJ and visual artist, had been men’s artistic director for Vuitton, the world’s biggest luxury brand, since March 2018.

He founded the Italian luxury streetwear label Off-White, in which LVMH took a 60% stake earlier this year. He was a former collaborator with rapper and fashion designer Ye, formerly known as Kanye West, who dedicated his latest Sunday Service to Abloh...